Research
Notal Vision’s commitment to evidence-based medicine is a founding principle on which the company continues to focus today. The National Eye Institute is currently conducting an ancillary study to AREDS2 with the ForeseeHome AMD Monitor. Notal Vision has worked with leading experts in the field to establish the highest standards of sensitivity and specificity for its products. Preferential Hyperacuity Perimetry has been clinically proven in numerous studies and thousands of patients with age-related macular degeneration.
Functional and Morphologic Benefits in Early Detection of
Neovascular Age-Related Macular Degeneration Using the Preferential Hyperacuity
Perimeter
RETINA 2011; Epub: 1-7
“The present study found that Group 2 participants who were monitored with the PHP had conversion to nvAMD detected at a much earlier stage than Group 1 participants.”
“Eyes with nvAMD lesions detected by PHP had smaller lesions and better function when compared with the group before the introduction of PHP.”
“[PHP] has been shown to detect choroidal neovascularization with a sensitivity twice as high as the Amsler Grid.”
Toward Earlier Detection of Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
RETINA 2010; 30:1058-1064
"A home device preferential hyperacuity perimeter has good sensitivity and specificity."
"The home device can distinguish between patients with newly diagnosed CNV and intermediate AMD with an average sensitivity and specificity of 85%."
Long Term Monitoring of Age-Related Macular Degeneration with Preferential Hyperacuity Perimetry
OSLI 2010: 598-606 
“PHP is useful for detecting CNV in regularly monitored eyes with intermediate AMD while maintaining a low false-positive rate.”
“The ability to rely on PHP as a complimentary tool for early detection of CNV provides an earlier opportunity to initiate treatment of CNV, thereby increasing the likelihood of favorable long-term visual prognosis.”
“Increasing the frequency of monitoring, the use of the PHP test may prove instrumental in assisting early diagnosis of CNV, thereby significantly improving the visual outcome of treatment.
Replacing the Amsler Grid, A New Method for Monitoring Patients with Age-Related Macular Degeneration
Ophthalmology 2003; 110: 966-970
"Of the 32 patients with CNV, 30 (94%) were found positive on the PHP and 11 (34%) were found positive on the Amsler Grid."
"The PHP was superior to the Amsler Grid in detecting AMD related lesions."
"The results confirmed the observations of others regarding the poor validity of the Amsler Grid in detecting the neovascular form of AMD."
Preferential Hyperacuity Perimetry for Detecting Choroidal Neovascularization Study
Ophthalmology 2005; 112: 1758-1765
"PHP testing can detect recent-onset CNV resulting from AMD and can differentiate it from an intermediate stage of AMD with high sensitivity and specificity."
"These data suggest that monitoring with PHP should detect most cases of CNV of recent onset with few false-positive results at a stage when treatment usually would be beneficial. Thus, this monitoring should be considered in the management of the intermediate stage of AMD."
Results of a Multicenter Clinical Trial to Evaluate the Preferential Hyperacuity Perimeter for Detection of Age-Related Macular Degeneration
RETINA 2005; 25: 296-303
"PHP had a greater sensitivity than the Amsler Grid in detecting AMD related lesions after standardized protocol."
"The study verified the ability of the specifically developed algorithm to produce real time automatic analysis and objective standardized interpretation according to the patient's responses."
"The results confirmed the observations of other researchers regarding the poor validity of the Amsler Grid in detecting the neovascular form of AMD. "
